Lupus Rash as a base Sign of Autoimmune Disease

Lupus generates a wide range of symptoms and habitancy with the disease touch them at dissimilar intensities. Lupus involves abnormal action of the immune system. The dysfunctional immune system produces antibodies that turn against wholesome body cells and tissues (antinuclear antibodies). Some antibodies produced by the dysfunctional immune system can even alter the body's genetic material (anti-Dna antibodies). The abnormal action of the immune system can lead to the occurrence of various internal disorders (heart disease, pulmonary disease, kidney disease), disorders of the musculoskeletal system (arthritis, osteoporosis), disorders of the nervous system (brain disease) and skin diseases (lupus rash, erythematous lesions).

In spite of the fact that patients with the autoimmune disease commonly have dissimilar symptoms, rash is a base sign of lupus. Lupus rash is characteristic to both systemic and discoid forms of the disease and it is normally the first symptom to appear. Lupus is a persisting disease and its generated symptoms reoccur on a quarterly time basis. Although other symptoms may come and go, lupus rash is very persistent and difficult to overcome.

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Lupus rash commonly occurs on the body regions that are exposed to sunlight: scalp, face, neck and shoulders. However, the rash can also occur in other areas of the body (chest, back, palms and feet), in many cases accompanied by skin lesions. When it occurs on the face, lupus rash has a reddish, burn-like aspect. Sometimes the rash can even affect the moist tissues colse to the mouth and the nose. In the systemic form of the disease, lupus rash doesn't commonly involve skin scarring and it can ameliorate with curative treatment. Lupus rash tends to aggravate if the affected skin is exposed to the sun for long periods of time.

Lupus Rash as a base Sign of Autoimmune Disease

Panic Disorder: The Facts Best

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Panic Disorder: The Facts Overview

Panic disorder is a remarkably common psychological condition, characterized by sudden attacks of intense fear and panic. Approximately 3% of the population will experience some aspect of panic disorder during their lifetime. Incredibly distressing, it can have an adverse effect on most aspects of the person's life, especially if chronic.

This new edition of Panic Disorder: The Facts includes valuable new information on treatment and discusses the relationship between panic disorder and other anxiety conditions. It also assesses the evidence for the available treatments, drawing from the latest scientific research. Up-to-date information on the nature, symptoms, causes, theories, and treatment of panic disorder is provided, all in non-technical language. The chapters on treatment give a detailed account of psychological therapy and also discuss drug treatment. Numerous personal accounts are given throughout the book, highlighting various aspects of panic disorder and its treatment and management.

Though mainly intended for sufferers of panic disorder, and their families and friends, it will also be of interest to the general reader, and to health care workers.

Clearly written by two leading experts, the book is a valuable source of information for anyone affected by this disorder.

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In the discoid form of lupus, the rash occurs in dissimilar regions of the body and it affects larger patches of skin. Discoid lupus rash involves hyperpigmentation of the skin, exfoliation and the formation of crust. The skin lesions characteristic to discoid lupus erythematosus can affect deeper layers of skin and they normally heal with scarring. When it occurs on the scalp, discoid lupus rash can involve temporary or permanent hair loss (alopecia). If the rash is accompanied by intense scaling, papules and crust, the skin may heal with pronounced scarring.

Subacute cutaneous lupus rash commonly occurs in the body areas that are exposed to the sun. The rash increases in size and it forms circular, scaly patches. This type of lupus rash doesn't involve scarring, but it normally heals with hypo-pigmentation of the skin. Subacute cutaneous lupus rash can occur in both systemic and discoid forms of the disease and it commonly fades in the periods of remission. Although it can't be thoroughly overcome, this symptom can also be controlled through the means of curative treatments. When you have lupus rash, it is very important to avoid exposing the affected skin to sunlight. Also, you should avoid exposing the skin to irritants and chemicals, as they can seriously aggravate the rash.

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The Facts About Glutathione and Parkinson's Disease

Parkinson's Disease (Pd), a devastating illness, occurs in one of every 100 people over 65.

It is a gradually progressing disease of the nervous system that results in progressive destruction of brain cells (neurons) in an area of the brain called the substantia nigra. Death occurs normally as a result of secondary complications such as infection.

Nervous System Facts

One of the mechanisms known to destroy neurons is damage by free radicals or reactive oxygen species - destructive molecules produced by oxidation of the neurotransmitter dopamine.

The Facts About Glutathione and Parkinson's Disease

Epilepsy: The Facts (Facts Series) Best

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Epilepsy: The Facts (Facts Series) Overview

Epilepsy: The Facts, written by a neurologist and a pediatric neurologist, explains in clear and simple terms everything about the causes and effects of epilepsy. This book, strengthened by the contributions of a new new coauthor, has been considerably revised for the new edition. Intended for sufferers of epilepsy and their relatives, the authors explain what is meant by epilepsy, describe different types of epileptic seizure and of epilepsy syndromes in childhood and adult life, and offer an explanation of how epilepsy is investigated. Recent advances in the management of epilepsy by the use of drugs and therapy are considered in depth, as is the impact of new imaging techniques. The authors emphasize throughout the positive possibilities for people with epilepsy as well as advising on how to cope with problems as and when they arise in day-to-day living. They take many aspects of a normal life such as schooling, pregnancy, driving, and work, and describe how epilepsy can affect these. In the final chapter, the future of epilepsy is covered. The authors have succeeded in making this complex field interesting and understandable for people with epilepsy and their relatives.

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The Role of Dopamine

The cells of the substantia nigra use dopamine - a chemical messenger in the middle of brain or nerve cells - to impart with cells in another region of the brain called the striatum.

When nigral cells are lost, nigral dopamine levels fall, resulting in a decrease in striatal dopamine.

The typical symptoms of Pd - motor function deficiencies characterized by muscle rigidity, jerky movements, rhythmic resting tremors - are the result of low levels of striatal dopamine.

Most dopaminergic drugs used to treat Pd, are aimed at temporarily replenishing or mimicking dopamine. They improve some symptoms, but do not restore general brain function nor halt brain cell destruction.

Dopaminergic drugs are generally effective at first in reducing many Pd symptoms, but over time they lose their effect.

They also cause severe side effects because they overstimulate nerve cells elsewhere in the body and cause confusion, hallucinations, nausea and fluctuations in the movement of limbs.

The Role of Antioxidants

When dopaminergic neurons are lost in the course of Parkinson's disease, the metabolism of dopamine is increased - which in turn increases the formation of very neurotoxic hydroxyl radicals.

The most important free radical scavenger in the cells of the substantia nigra is the powerful brain antioxidant, glutathione. Glutathione levels in Pd patients are low.

And as we age, levels of glutathione in the dopaminergic neurons of the substantia nigra decreases. This appears to railroad cell death and expand the progression of Pd.

At least 80 percent of the substantia nigra cells are lost before symptoms of Parkinson's disease come to be apparent. This is why it becomes requisite to safe or enounce these cells under oxidative stress.

How does Glutathione help in Parkinson's Disease?

Several factors clarify why glutathione is so beneficial in Parkinson's disease.

1. Glutathione increases the sensitivity of the brain to dopamine. So although glutathione doesn't raise dopamine levels, it allows the dopamine in the brain to be more effective.

2. Glutathione's powerful antioxidant performance protects the brain from free radical damage.

3. An even more entertaining advantage of glutathione lies in its powerful detoxification ability.

Its a well known fact that most Parkinson's patients are deficient in their quality to detoxify chemicals to which they are exposed.

The unfortunate few who harbor an inherited flaw in their detoxification pathways are at far greater risk to the brain damaging effects of a wide collection of toxins.

Glutathione is one of the most important components of the liver's detoxification system. Glutathione therapy is one of the most effective techniques for improving liver and brain detoxification.

Glutathione treatments considerably improve some of the symptoms of Parkinson's disease including difficulties with rigidity, walking, movement, coordination and speech. A marked allowance of tremor has been observed as well as a decrease in depression.

Glutathione and N-acetyl-L-cysteine (a glutathione precursor) have been shown to be very effective in protecting the nerves in the substantia nigra from being destroyed by oxidative stress.

Glutathione Therapy in Parkinson's Disease

The practical problem in addition glutathione levels is that taking glutathione itself as a supplement does not boost cellular glutathione levels, since glutathione breaks down in the digestive tract before it reaches the cells.

However, intravenous glutathione therapy and taking glutathione precursors are both effective in boosting intracellular levels of glutathione.

Intravenous Glutathione Therapy:

Intravenous glutathione injections have been shown to have fantastic and quick results.

Dr. David Perlmutter, a pioneer in this therapy, has industrialized a protocol utilized at the Perlmutter condition center for administering intravenous glutathione to Parkinson's patients.

Following even a single dosage of intravenous glutathione - often in as petite as 15 minutes - the quality to walk, turn nearby and move their arms is practically completely restored.

Glutathione Precursors:

Dietary antioxidants and supplements that growth cellular glutathione, such as alpha lipoic acid, Nac, pycnogenol, the herb silymarin (milk thistle), are effective in restoring general function.

N-acetyl-cysteine (Nac) and un-denatured, whey protein both contribute glutathione precursors intracellularly, improve the body's production of glutathione and aid the detoxification process.

Other nutritional supplements which aid the detoxification process comprise selenium, vitamins E and C.

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Check Out Huntington's Disease: The Facts for $36.16

Huntington's Disease: The Facts Quality Best

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Huntington's Disease: The Facts Overview

Huntington's Disease is a genetically inherited condition, the result of severe nerve-cell damage in the brain. Due to the recent identification of the gene involved, and the debilitating nature of the disease, a great many more people are now affected either directly or indirectly (families and carers) by this condition. The majority of people develop the disease between the ages of 35 and 55, so for those that are aware of a genetic inheritance, there are enormous problems to confront - should you carry on life as normal? Should you start a family? In this, the first book on Huntington's disease written for sufferers and their families, advice is given on living with this disabling illness. Written as much for carers as for the patients themselves, the book aims to answer some of the questions that both sufferer and carer might have. With the identification of the responsible gene, genetic counselling is now available for those at risk of developing the disease. Though some may wish not to use these services, the book clearly explains the role of the counsellor, and what help is additionally available from the various patient organisations worldwide.

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