The Facts About Glutathione and Parkinson's Disease

Parkinson's Disease (Pd), a devastating illness, occurs in one of every 100 people over 65.

It is a gradually progressing disease of the nervous system that results in progressive destruction of brain cells (neurons) in an area of the brain called the substantia nigra. Death occurs normally as a result of secondary complications such as infection.

Nervous System Facts

One of the mechanisms known to destroy neurons is damage by free radicals or reactive oxygen species - destructive molecules produced by oxidation of the neurotransmitter dopamine.

The Facts About Glutathione and Parkinson's Disease

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Epilepsy: The Facts (Facts Series) Overview

Epilepsy: The Facts, written by a neurologist and a pediatric neurologist, explains in clear and simple terms everything about the causes and effects of epilepsy. This book, strengthened by the contributions of a new new coauthor, has been considerably revised for the new edition. Intended for sufferers of epilepsy and their relatives, the authors explain what is meant by epilepsy, describe different types of epileptic seizure and of epilepsy syndromes in childhood and adult life, and offer an explanation of how epilepsy is investigated. Recent advances in the management of epilepsy by the use of drugs and therapy are considered in depth, as is the impact of new imaging techniques. The authors emphasize throughout the positive possibilities for people with epilepsy as well as advising on how to cope with problems as and when they arise in day-to-day living. They take many aspects of a normal life such as schooling, pregnancy, driving, and work, and describe how epilepsy can affect these. In the final chapter, the future of epilepsy is covered. The authors have succeeded in making this complex field interesting and understandable for people with epilepsy and their relatives.

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The Role of Dopamine

The cells of the substantia nigra use dopamine - a chemical messenger in the middle of brain or nerve cells - to impart with cells in another region of the brain called the striatum.

When nigral cells are lost, nigral dopamine levels fall, resulting in a decrease in striatal dopamine.

The typical symptoms of Pd - motor function deficiencies characterized by muscle rigidity, jerky movements, rhythmic resting tremors - are the result of low levels of striatal dopamine.

Most dopaminergic drugs used to treat Pd, are aimed at temporarily replenishing or mimicking dopamine. They improve some symptoms, but do not restore general brain function nor halt brain cell destruction.

Dopaminergic drugs are generally effective at first in reducing many Pd symptoms, but over time they lose their effect.

They also cause severe side effects because they overstimulate nerve cells elsewhere in the body and cause confusion, hallucinations, nausea and fluctuations in the movement of limbs.

The Role of Antioxidants

When dopaminergic neurons are lost in the course of Parkinson's disease, the metabolism of dopamine is increased - which in turn increases the formation of very neurotoxic hydroxyl radicals.

The most important free radical scavenger in the cells of the substantia nigra is the powerful brain antioxidant, glutathione. Glutathione levels in Pd patients are low.

And as we age, levels of glutathione in the dopaminergic neurons of the substantia nigra decreases. This appears to railroad cell death and expand the progression of Pd.

At least 80 percent of the substantia nigra cells are lost before symptoms of Parkinson's disease come to be apparent. This is why it becomes requisite to safe or enounce these cells under oxidative stress.

How does Glutathione help in Parkinson's Disease?

Several factors clarify why glutathione is so beneficial in Parkinson's disease.

1. Glutathione increases the sensitivity of the brain to dopamine. So although glutathione doesn't raise dopamine levels, it allows the dopamine in the brain to be more effective.

2. Glutathione's powerful antioxidant performance protects the brain from free radical damage.

3. An even more entertaining advantage of glutathione lies in its powerful detoxification ability.

Its a well known fact that most Parkinson's patients are deficient in their quality to detoxify chemicals to which they are exposed.

The unfortunate few who harbor an inherited flaw in their detoxification pathways are at far greater risk to the brain damaging effects of a wide collection of toxins.

Glutathione is one of the most important components of the liver's detoxification system. Glutathione therapy is one of the most effective techniques for improving liver and brain detoxification.

Glutathione treatments considerably improve some of the symptoms of Parkinson's disease including difficulties with rigidity, walking, movement, coordination and speech. A marked allowance of tremor has been observed as well as a decrease in depression.

Glutathione and N-acetyl-L-cysteine (a glutathione precursor) have been shown to be very effective in protecting the nerves in the substantia nigra from being destroyed by oxidative stress.

Glutathione Therapy in Parkinson's Disease

The practical problem in addition glutathione levels is that taking glutathione itself as a supplement does not boost cellular glutathione levels, since glutathione breaks down in the digestive tract before it reaches the cells.

However, intravenous glutathione therapy and taking glutathione precursors are both effective in boosting intracellular levels of glutathione.

Intravenous Glutathione Therapy:

Intravenous glutathione injections have been shown to have fantastic and quick results.

Dr. David Perlmutter, a pioneer in this therapy, has industrialized a protocol utilized at the Perlmutter condition center for administering intravenous glutathione to Parkinson's patients.

Following even a single dosage of intravenous glutathione - often in as petite as 15 minutes - the quality to walk, turn nearby and move their arms is practically completely restored.

Glutathione Precursors:

Dietary antioxidants and supplements that growth cellular glutathione, such as alpha lipoic acid, Nac, pycnogenol, the herb silymarin (milk thistle), are effective in restoring general function.

N-acetyl-cysteine (Nac) and un-denatured, whey protein both contribute glutathione precursors intracellularly, improve the body's production of glutathione and aid the detoxification process.

Other nutritional supplements which aid the detoxification process comprise selenium, vitamins E and C.

The Facts About Glutathione and Parkinson's DiseasePrograma Transição N01 Mediunidade 1-3 (SUBTITLED!!!) Video Clips. Duration : 9.98 Mins.

Programa Transição Nº 01 05/10/2008 Tema: Mediunidade Participação: Divaldo Franco www.transicao.tv.br LEGENDADO EM INGLÊS SUBTITLED IN ENGLISH Transition Program Nº 01 05/10/2008 Theme: Mediumship Participation: Divaldo Franco www.transicao.tv.br

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